Diversity of receptors binding HIV on dendritic cell subsets

  title={Diversity of receptors binding HIV on dendritic cell subsets},
  author={S. Turville and P. Cameron and A. Handley and G. Lin and S. P{\"o}hlmann and R. Doms and A. Cunningham},
  journal={Nature Immunology},
  • S. Turville, P. Cameron, +4 authors A. Cunningham
  • Published 2002
  • Biology, Medicine
  • Nature Immunology
  • The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was predominant in skin DCs, whereas binding to emigrating and tonsil DCs was CD4-dependent. No one CLR was solely responsible for envelope binding on all skin DC subsets. DC-SIGN (DC… CONTINUE READING
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