Diversity of receptors binding HIV on dendritic cell subsets

@article{Turville2002DiversityOR,
  title={Diversity of receptors binding HIV on dendritic cell subsets},
  author={Stuart G Turville and Paul U. Cameron and Amanda J. Handley and George Lin and Stefan P{\"o}hlmann and Robert W. Doms and Anthony L Cunningham},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={975-983}
}
The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was predominant in skin DCs, whereas binding to emigrating and tonsil DCs was CD4-dependent. No one CLR was solely responsible for envelope binding on all skin DC subsets. DC-SIGN (DC… Expand
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Dendritic cells play a major role in HIV pathogenesis and appear to be one of the first cells infected after sexual transmission and transfer of the virus to CD4 lymphocytes, simultaneously activating these cells to produce high levels of HIV replication. Expand
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Observations help to explain the greater ability of mature DCs to transfer HIV-1 to T lymphocytes, a process that can potentially contribute to the viral dissemination at lymph nodes in vivo, where viral replication takes place and there is a continuous interaction between susceptible T cells and matureDCs. Expand
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New facts regarding the binding, uptake, and processing of chemically inactivated virions leading to efficient antigen presentation are brought forth and should aid in the design of more effective HIV vaccines. Expand
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Results indicate that DC-SIGN has the potential to contribute to macrophage function in normal human lymph node, and that DCs do not requireDC-SIGN to transmit HIV or to initiate T cell responses. Expand
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It is demonstrated that the type I IFN-inducible Siglec-1, CD169, is the DC receptor that captures HIV in a GM3-dependent manner, and a novel mechanism of pathogen parasitization of host encoded cellular recognition machinery (GM3 – CD169 interaction) for DC-dependent HIV dissemination is described. Expand
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References

SHOWING 1-10 OF 54 REFERENCES
HIV gp120 receptors on human dendritic cells.
TLDR
A novel biotinylated gp120 assay was used to determine whether CLR or CD4 were predominant receptors on monocyte-derived DCs and ex vivo blood DCs, and confirmed that CLRs were the major receptors for gp120 on MDDCs. Expand
Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways.
TLDR
It is suggested that strategies designed to block mucosal transmission of HIV should consider interfering with both virus infection and virus capture by DC. Expand
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
TLDR
It is proposed that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells. Expand
The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection.
TLDR
Data suggest a linkage between CD40-CD40L and CD28-CD80 counterreceptors on DCs and T cells, and spread of HIV infection in vivo. Expand
Bitter-sweet symphony: defining the role of dendritic cell gp120 receptors in HIV infection.
  • S. Turville, P. Cameron, +4 authors A. Cunningham
  • Biology, Medicine
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2001
TLDR
It is clear that immature MDDC have a complex pattern of HIV gp120 binding, in contrast to other cell types gp120 has the potential to bind to several receptors on DC including CD4 and several types of C type lectin receptor, not just exclusively DC-SIGN. Expand
The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells1
TLDR
It is demonstrated that on DCs DC-SIGN is rapidly internalized upon binding of soluble ligand, which points to a novel function of the adhesion receptor DC- SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity. Expand
Dendritic cells and the replication of HIV‐1
TLDR
The literature leads to the hypothesis that HIV‐1 infection is a battleground in which DCs could be leading both of the armies, the aggressor that promotes HIV‐ 1 replication from relatively small numbers of infected cells and the defender that mediates T cell‐dependent resistance. Expand
Interaction of Human Epidermal Langerhans Cells with HIV‐1 Viral Envelope Proteins (gp 120 and gp 160s) Involves a Receptor‐mediated Endocytosis Independent of the CD4 T4A Epitope
TLDR
It is reported that human Langerhans cells can bind the viral envelope proteins (gp 120 or gp 160s), and that this binding does not depend on CD4 protein expression, and that a proportion of gp 120/gp 160s‐receptor complexes enters LangerHans cells by a process identified as a receptor‐mediated endocytosis. Expand
DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus
TLDR
Investigating the structural determinants of DC-SIGN required for virus binding and transmission to permissive cells found that R5, X4, and R5X4 HIV-1 isolates as well as simian immunodeficiency and HIV-2 strains bound toDC-SIGN and could be transmitted to CD4/coreceptor-positive cell types. Expand
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
TLDR
It is proposed that conjugates of dendritic cells and T cells, as found in the external linings of organs involved in sexual transmission of HIV-1, represent an important site for the productive phase of HIV, providing a mechanism for the chronic depletion of CD4+ memory cells in HIV- 1 disease. Expand
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