Diversity of receptors binding HIV on dendritic cell subsets

@article{Turville2002DiversityOR,
  title={Diversity of receptors binding HIV on dendritic cell subsets},
  author={Stuart G Turville and Paul U. Cameron and Amanda J. Handley and George Lin and Stefan P{\"o}hlmann and Robert W. Doms and Anthony L Cunningham},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={975-983}
}
The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was predominant in skin DCs, whereas binding to emigrating and tonsil DCs was CD4-dependent. No one CLR was solely responsible for envelope binding on all skin DC subsets. DC-SIGN (DC… Expand
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