Diversity of progesterone action on lipopolysaccharide-induced expression changes in cultured human cervical fibroblasts according to inflammation and treatment timing.

@article{Kuwabara2017DiversityOP,
  title={Diversity of progesterone action on lipopolysaccharide-induced expression changes in cultured human cervical fibroblasts according to inflammation and treatment timing.},
  author={Yoshimitsu Kuwabara and Akira Katayama and Sachiko Kurihara and Marie D'Aguanno Ito and Mirei Yonezawa and Nozomi Ouchi and Ryuhei Kurashina and Tomoko Ichikawa and Rintaro Sawa and Akihito Nakai and Hideo Orimo and Toshiyuki Takeshita},
  journal={American journal of reproductive immunology},
  year={2017},
  volume={78 5}
}
PROBLEM The effectiveness of progesterone (P4) treatment for preventing preterm births is unclear. Its effects on the uterine cervix were tested using cultured human uterine cervical fibroblasts (UCFs). METHOD OF STUDY UCFs were incubated with lipopolysaccharide (LPS) in the presence or absence of P4 under various conditions. mRNA was subjected to PCR arrays and real-time RT-PCR to assess IL-6, IL-8, IL-1beta, PTGS2, MMP-1, and CXCL10 expression. RESULTS When exposed to a high-LPS… CONTINUE READING

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