Diversity of ovarian steroid signaling in the hypothalamus.

  title={Diversity of ovarian steroid signaling in the hypothalamus.},
  author={Oline K R\onnekleiv and Martin J Kelly},
  journal={Frontiers in neuroendocrinology},
  volume={26 2},
It is well known that many of the actions of gonadal steroids in hypothalamic neurons are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. Since the cloning of the intracellular steroid receptors/transcription factors, it has been assumed that most if not all of the actions of the gonadal steroids are mediated via these intracellular receptors. However, there now exist compelling evidence for membrane (G-protein-coupled… CONTINUE READING
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