Diversity of mitochondrial genome organization

  title={Diversity of mitochondrial genome organization},
  author={A. A. Kolesnikov and Evgeny S Gerasimov},
  journal={Biochemistry (Moscow)},
In this review, we discuss types of mitochondrial genome structural organization (architecture), which includes the following characteristic features: size and the shape of DNA molecule, number of encoded genes, presence of cryptogenes, and editing of primary transcripts. 

Mitochondrial genome structure of photosynthetic eukaryotes

Data on the size and structural organization of mtDNA, gene content, and peculiarities are summarized and special emphasis is given to characteristic features of the mitochondrial genomes of land plants and photosynthetic algae that distinguish them from the mitochondria of other eukaryotes.

The mitochondrial genome. The nucleoid

Questions needing answers for better understanding of the fine mechanisms of the mitochondrial genetic apparatus functioning are discussed and the currently accepted model of nucleoid organization is described.

A novel fragmented mitochondrial genome in the protist pathogen Toxoplasma gondii and related tissue coccidia

The independent evolution of fragmented cytochrome genes in Toxoplasma and related tissue coccidia and evolution of a novel genome architecture consisting minimally of 21 sequence blocks (SBs) that exist as non-random concatemers are reported.

Mitochondrial RNA Turnover in Metazoa

Recent insights into mitochondrial gene expression are described, focusing on observations made in the fruit fly, Drosophila melanogaster, which shows functional conservation with the human system.

Plant mitochondrial DNA.

Plants possess mitochondrial genomes that are large and complex compared to animals, but despite their size, plant mitochondrial genomes do not contain significantly more genes than their animal counterparts.

An Insight Into the Mechanism of Plant Organelle Genome Maintenance and Implications of Organelle Genome in Crop Improvement: An Update

Understanding the mechanism of DNA damage repair and inter compartmental crosstalk mechanism in various sub-cellular organelles following induction ofDNA damage and identification of key components of such signaling cascades may eventually be translated into strategies for crop improvement under abiotic and genotoxic stress conditions.

Complete vertebrate mitogenomes reveal widespread gene duplications and repeats

Modern sequencing technologies should make the assembly of the relatively small mitochondrial genomes an easy undertaking. However, few tools exist that address mitochondrial assembly directly. As

Introduction to Genome Biology and Diversity.

This chapter reviews how the genome can be viewed as both a structural and an informational unit of biological diversity and explicitly define the intended meaning of genetic information.

Complete vertebrate mitogenomes reveal widespread repeats and gene duplications

The results indicate that even in the “simple” case of vertebrate mitogenomes the completeness of many currently available reference sequences can be further improved, and caution should be exercised before claiming the complete assembly of a mitogenome, particularly from short reads alone.



RNA editing gives a new meaning to the genetic information in mitochondria and chloroplasts

Influences of the nuclear genome on editing patterns suggest that cytoplasmic factors participate in this process of C-to-U transitions in plant mitochondria and chloroplasts.

Reduction of the Edited Domain of the Mitochondrial A6 Gene for ATPase Subunit 6 in Trypanosomatidae

The sequence of mitochondrial A6 (MURF4) was compared for several trypanosomatid species and the association between the ED reduction and the phylogenetic position of a species proved to be less tight than believed earlier.

Evolution of organellar genomes.

  • M. Gray
  • Biology
    Current opinion in genetics & development
  • 1999

Similarity of the edited sequences of Leishmania kinetoplast geneMURF4 (ATPase6)

The primary structure of the edited part of the MURF4 (ATPase6) gene was compared for seven species of flagellate Leishmania and the sequences proved to be highly homologous.

RNA editing in plant mitochondria.

Current research focuses on the elucidation of the biochemistry and the specificity determinants of RNA editing in plant mitochondria.

The complete nucleotide sequence and multipartite organization of the tobacco mitochondrial genome: comparative analysis of mitochondrial genomes in higher plants

The complete mtDNA sequence of Nicotiana tabacum is determined and it is revealed that there are four classes of boundaries derived from homologous recombination, which leads to a multipartite organization with two MCs and six subgenomic circles.

Phylogenetic analysis of RNA editing: a primitive genetic phenomenon.

  • L. LandweberW. Gilbert
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1994
The results suggest that extensive editing is a primitive genetic phenomenon that has disappeared in recent evolutionary time and also that there have been multiple losses of the digenetic lifestyle by loss of the vertebrate host in parasite evolution.

Unique mitochondrial genome architecture in unicellular relatives of animals

It is posited that the distinct compaction characteristic of metazoan mitochondrial genomes occurred simultaneously with the emergence of a multicellular body plan in the animal lineage.