Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines

@article{Sato1999DiversityOM,
  title={Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines},
  author={Kazuo Z. Sato and T. Fujii and Yoshihiro Watanabe and S. Yamada and Tsuyoshi Ando and Fujimoto Kazuko and K. Kawashima},
  journal={Neuroscience Letters},
  year={1999},
  volume={266},
  pages={17-20}
}
Previously, we reported that various levels of acetylcholine (ACh), currently known as a neurotransmitter, are detectable in the blood of several mammals including humans and that most blood ACh originates from T-lymphocytes. To investigate whether ACh in the blood acts on lymphocytes and participates in the modulation of immune responses, we have analyzed the expression of mRNA for muscarinic (Ms) ACh receptor subtypes and nicotinic (Nc) ACh receptor subunits using reverse transcription… Expand
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Findings indicate that ACh synthesized by ChAT in T-lymphocytes acts on the muscarinic receptors on lymphocytes in autocrine and/or paracrine pathways and suggest that A Ch in blood functions as a modulator of T-cell-dependent immune responses. Expand
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