Diversity of lipopolysaccharide structures in Campylobacter jejuni.


Immune blots of electrophoresed lipopolysaccharides extracted from 38 Campylobacter jejuni serostrains suggested the presence of O chains in 16 strains and their absence in 22. Structural analysis confirmed the presence of O chains in serostrains O:19, O:23, and O:36 and the absence of O chains in serostrains O:1, O:2, and O:3. The O:19 strain has O repeat units of beta-D-glucuronic acid amidated with 2-amino-2-deoxyglycerol and N-acetylglucosamine. The 0:36 O chain has four different but closely related repeat units that each consist of N-acetylglucosamine, galactose, and a heptose that is varied in structure from one repeat unit to the next. The O:23 O chain has three different repeat units identical to three of O:36. Except for O:3, core oligosaccharides of strains with or without O chains contain sialic acid (Neu5Ac) in the terminal regions that in many cases mimic the structures of human gangliosides. Three neuropathic isolates were found to have a core terminal trisaccharide (Neu5Ac alpha2-->8Neu5Ac alpha2-->3Galbeta1) that was not found in nonneuropathic strains.

Citations per Year

109 Citations

Semantic Scholar estimates that this publication has 109 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Penner1997DiversityOL, title={Diversity of lipopolysaccharide structures in Campylobacter jejuni.}, author={Janice L Penner and Gerald O Aspinall}, journal={The Journal of infectious diseases}, year={1997}, volume={176 Suppl 2}, pages={S135-8} }