Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.

@article{Jones2013DiversityOL,
  title={Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.},
  author={Bryony Leigh Jones and Tamiru Oljira Raga and Anke Liebert and Pawel Zmarz and Endashaw J. Bekele and E Thomas Danielsen and Anders Kr{\"u}ger Olsen and Neil N Bradman and Jesper Thorvald Troelsen and Dallas M Swallow},
  journal={American journal of human genetics},
  year={2013},
  volume={93 3},
  pages={538-44}
}
The persistent expression of lactase into adulthood in humans is a recent genetic adaptation that allows the consumption of milk from other mammals after weaning. In Europe, a single allele (-13910(∗)T, rs4988235) in an upstream region that acts as an enhancer to the expression of the lactase gene LCT is responsible for lactase persistence and appears to have been under strong directional selection in the last 5,000 years, evidenced by the widespread occurrence of this allele on an extended… CONTINUE READING
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