Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

@inproceedings{Leplae2011DiversityOB,
  title={Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families},
  author={Rapha{\"e}l Leplae and Damien Geeraerts and R{\'e}gis Hallez and Julien Guglielmini and Pierre L Dr{\`e}ze and Laurence Van Melderen},
  booktitle={Nucleic acids research},
  year={2011}
}
Type II toxin-antitoxin (TA) systems are generally composed of two genes organized in an operon, encoding a labile antitoxin and a stable toxin. They were first discovered on plasmids where they contribute to plasmid stability by a phenomenon denoted as 'addiction', and subsequently in bacterial chromosomes. To discover novel families of antitoxins and toxins, we developed a bioinformatics approach based on the 'guilt by association' principle. Extensive experimental validation in Escherichia… CONTINUE READING
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