Diversity of bacterial manipulation of the host ubiquitin pathways.

  title={Diversity of bacterial manipulation of the host ubiquitin pathways.},
  author={Yan Ping Zhou and Yongqun Zhu},
  journal={Cellular microbiology},
  volume={17 1},
Ubiquitination is generally considered as a eukaryotic protein modification, which is catalysed by a three-enzyme cascade and is reversed by deubiquitinating enzymes. Ubiquitination directs protein degradation and regulates cell signalling, thereby plays key roles in many cellular processes including immune response, vesicle trafficking and cell cycle. Bacterial pathogens inject a series of virulent proteins, named effectors, into the host cells. Increasing evidence suggests that many effectors… CONTINUE READING
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