Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns

@article{Munroe2004DiversityOA,
  title={Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns},
  author={Stephen H. Munroe},
  journal={Journal of Cellular Biochemistry},
  year={2004},
  volume={93}
}
  • S. H. Munroe
  • Published 1 November 2004
  • Biology
  • Journal of Cellular Biochemistry
High‐throughput analysis of RNA molecules in multicellular eukaryotes has revealed an abundance of complementary antisense RNAs that are transcribed from separate or overlapping genes. In mammals these include many novel non‐coding RNAs of unknown function. This unexpected complexity of the mammalian transcriptome suggests that expression of many genes is regulated post‐transcriptionally by mechanisms mediated by RNA–RNA base pairing. The recent discovery of the widespread expression of… 
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Bioinformatic analysis of the transcriptomes of diverse eukaryotes has demonstrated the ubiquity and structural diversity of complementary antisense RNAs and suggested a number of other mechanisms that may not require formation of dsRNA.
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The approaches used in mammalian RNAi research, the current status of its applications to livestock systems and will discuss potential applications in beef cattle programs are examined.
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There is significant shortage of SA genes on Chromosome X in human and mouse but not in fly or worm, supporting X-inactivation in mammals as a possible cause, and identifying cis-NATs in 10 eukaryotic species.
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This chapter focuses on the function and molecular architecture of those proteins that interact with double-stranded RNA and that are key players in the RNA interference, editing and the PKR response.
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