Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns

@article{Munroe2004DiversityOA,
  title={Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns},
  author={S. H. Munroe},
  journal={Journal of Cellular Biochemistry},
  year={2004},
  volume={93}
}
  • S. H. Munroe
  • Published 2004
  • Biology, Medicine
  • Journal of Cellular Biochemistry
    • High‐throughput analysis of RNA molecules in multicellular eukaryotes has revealed an abundance of complementary antisense RNAs that are transcribed from separate or overlapping genes. In mammals these include many novel non‐coding RNAs of unknown function. This unexpected complexity of the mammalian transcriptome suggests that expression of many genes is regulated post‐transcriptionally by mechanisms mediated by RNA–RNA base pairing. The recent discovery of the widespread expression of… CONTINUE READING
    View on Wiley
    ncbi.nlm.nih.gov
    32 Citations
    Background Citations
    12

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

      32 Citations
      Citation Type

      Citation Type

      Overlapping transcripts, double-stranded RNA and antisense regulation: A genomic perspective
      • 83
      Overlapping genes and antisense transcription in eukaryotes
      • 1
      Comparative genomic analysis of non-coding sequences and the application of RNA interference tools for bovine functional genomics
      • 1
      MacroRNA underdogs in a microRNA world: evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA.
      • 188
      Natural antisense transcripts: sound or silence?
      • 88
      • PDF
      Overlapping genes in vertebrate genomes
      • 99
      Natural antisense and noncoding RNA transcripts as potential drug targets.
      • 108
      Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species
      • 170
      • PDF
      Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas.
      • 90
      • PDF
      Protein Interactions with Double-Stranded RNA in Eukaryotic Cells
      • 2

      References

      SHOWING 1-10 OF 41 REFERENCES
      Antisense RNAs everywhere?
      • 99
      Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes
      • 325
      • PDF
      Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.
      • M. Kumar, G. Carmichael
      • Biology, Medicine
      • Proceedings of the National Academy of Sciences of the United States of America
      • 1997
      • 191
      • PDF
      Computational discovery of sense-antisense transcription in the human and mouse genomes
      • 193
      • PDF
      Widespread occurrence of antisense transcription in the human genome
      • 623
      • Highly Influential
      • PDF
      Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
      • 1,335
      • PDF
      RNA interference : RNA
      • 2,322
      MicroRNAs Genomics, Biogenesis, Mechanism, and Function
      • 29,183
      • PDF
      The Fate of dsRNA in the Nucleus A p54nrb-Containing Complex Mediates the Nuclear Retention of Promiscuously A-to-I Edited RNAs
      • 450
      RNA editing by adenosine deaminases that act on RNA.
      • B. Bass
      • Biology, Medicine
      • Annual review of biochemistry
      • 2002
      • 1,029
      • PDF