Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns

  title={Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns},
  author={S. H. Munroe},
  journal={Journal of Cellular Biochemistry},
  • S. H. Munroe
  • Published 2004
  • Biology, Medicine
  • Journal of Cellular Biochemistry
  • High‐throughput analysis of RNA molecules in multicellular eukaryotes has revealed an abundance of complementary antisense RNAs that are transcribed from separate or overlapping genes. In mammals these include many novel non‐coding RNAs of unknown function. This unexpected complexity of the mammalian transcriptome suggests that expression of many genes is regulated post‐transcriptionally by mechanisms mediated by RNA–RNA base pairing. The recent discovery of the widespread expression of… CONTINUE READING
    32 Citations

    Topics from this paper

    Overlapping transcripts, double-stranded RNA and antisense regulation: A genomic perspective
    • 83
    Overlapping genes and antisense transcription in eukaryotes
    • 1
    Natural antisense transcripts: sound or silence?
    • 88
    • PDF
    Overlapping genes in vertebrate genomes
    • 99
    Natural antisense and noncoding RNA transcripts as potential drug targets.
    • 108
    Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas.
    • 90
    • PDF
    Protein Interactions with Double-Stranded RNA in Eukaryotic Cells
    • 2


    Antisense RNAs everywhere?
    • 99
    Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes
    • 325
    • PDF
    Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.
    • M. Kumar, G. Carmichael
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1997
    • 191
    • PDF
    Widespread occurrence of antisense transcription in the human genome
    • 623
    • Highly Influential
    • PDF
    RNA interference : RNA
    • 2,322
    MicroRNAs Genomics, Biogenesis, Mechanism, and Function
    • 29,183
    • PDF
    RNA editing by adenosine deaminases that act on RNA.
    • B. Bass
    • Biology, Medicine
    • Annual review of biochemistry
    • 2002
    • 1,029
    • PDF