Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns
@article{Munroe2004DiversityOA, title={Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns}, author={S. H. Munroe}, journal={Journal of Cellular Biochemistry}, year={2004}, volume={93} }
High‐throughput analysis of RNA molecules in multicellular eukaryotes has revealed an abundance of complementary antisense RNAs that are transcribed from separate or overlapping genes. In mammals these include many novel non‐coding RNAs of unknown function. This unexpected complexity of the mammalian transcriptome suggests that expression of many genes is regulated post‐transcriptionally by mechanisms mediated by RNA–RNA base pairing. The recent discovery of the widespread expression of… CONTINUE READING
Topics from this paper
32 Citations
Overlapping transcripts, double-stranded RNA and antisense regulation: A genomic perspective
- Biology, Medicine
- Cellular and Molecular Life Sciences CMLS
- 2006
- 83
Overlapping genes and antisense transcription in eukaryotes
- Biology, Medicine
- Russian Journal of Genetics
- 2014
- 1
MacroRNA underdogs in a microRNA world: evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA.
- Biology, Medicine
- Biochimica et biophysica acta
- 2010
- 188
Natural antisense and noncoding RNA transcripts as potential drug targets.
- Biology, Medicine
- Drug discovery today
- 2006
- 108
Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species
- Biology, Medicine
- Nucleic acids research
- 2006
- 170
- PDF
Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas.
- Medicine, Biology
- Human molecular genetics
- 2005
- 90
- PDF
References
SHOWING 1-10 OF 41 REFERENCES
Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes
- Biology, Medicine
- Microbiology and Molecular Biology Reviews
- 1998
- 325
- PDF
Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1997
- 191
- PDF
Computational discovery of sense-antisense transcription in the human and mouse genomes
- Biology, Medicine
- Genome Biology
- 2002
- 193
- PDF
Widespread occurrence of antisense transcription in the human genome
- Biology, Medicine
- Nature Biotechnology
- 2003
- 623
- Highly Influential
- PDF
Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
- Biology, Medicine
- Nature Reviews Genetics
- 2004
- 1,335
- PDF
The Fate of dsRNA in the Nucleus A p54nrb-Containing Complex Mediates the Nuclear Retention of Promiscuously A-to-I Edited RNAs
- Biology, Medicine
- Cell
- 2001
- 450
RNA editing by adenosine deaminases that act on RNA.
- Biology, Medicine
- Annual review of biochemistry
- 2002
- 1,029
- PDF