Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression.

@article{Daniely2010DiversityOT,
  title={Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression.},
  author={Danielle Daniely and Joanna Kern and Anna Cebula and Leszek Ignatowicz},
  journal={Journal of immunology},
  year={2010},
  volume={184 12},
  pages={6865-73}
}
Medullary thymic epithelial cells expressing the Aire gene play a critical role in the induction of tolerance to tissue-specific Ags (TSAs). It was postulated that recognition of Aire-controlled TSAs by immature thymocytes results in the selection of natural CD4+Foxp3+ regulatory T cells (Tregs) and enriches this repertoire in self-reactive receptors, contributing to its vast diversity. In this study, we compared the TCRs on individual Tregs in Aire+ and Aire- mice expressing a miniature TCR… CONTINUE READING

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