Diversity of T-cell receptor alpha gene transcripts in the newborn and adult periphery

@article{Thompson2004DiversityOT,
  title={Diversity of T-cell receptor alpha gene transcripts in the newborn and adult periphery},
  author={S. Thompson and M. Larch{\'e} and A. R. Manzo and J. Hurwitz},
  journal={Immunogenetics},
  year={2004},
  volume={36},
  pages={95-103}
}
  • S. Thompson, M. Larché, +1 author J. Hurwitz
  • Published 2004
  • Biology, Medicine
  • Immunogenetics
    • Recent studies have demostrated that the diversity of T-cell receptor alpha (Tcra) gene expression may be confined by a developmental program for gene rearrangement. To examine the effect of age on Tcra gene usage in peripheral tissues, a comparison of Tcr transcripts from newborn and adult mouse splenocytes was made. RNA was first isolated from the spleens of newborn (within five days from birth) and adult B10.BR mice. The polymerase chain reaction was then used to assess the presence of Tcra… CONTINUE READING
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    References

    SHOWING 1-10 OF 36 REFERENCES
    Developmental T cell receptor gene rearrangements: Relatedness of the α/β and γ/δ T cell precursor
    • 37
    First T cell receptor alpha gene rearrangements during T cell ontogeny skew to the 5' region of the J alpha locus.
    • 78
    A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process.
    • 46
    Diversity, rearrangement, and expression of murine T cell gamma genes
    • 358
    Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires.
    • 157
    Nonrandom rearrangement of T cell receptor J alpha genes in bone marrow T cell differentiation cultures.
    • 19
    Immature and advanced patterns of T cell receptor gene rearrangement among lymphocytes in splenic culture.
    • 18
    Diversity and structure of genes of the α family of mouse T-cell antigen receptor
    • 192
    Rearrangement of T-cell receptor beta-chain genes during T-cell development.
    • 176
    • PDF
    T cell receptor gene usage in the response to lambda repressor cI protein. An apparent bias in the usage of a V alpha gene element
    • 44
    • PDF