Diversity of T-cell receptor alpha gene transcripts in the newborn and adult periphery

@article{Thompson2004DiversityOT,
  title={Diversity of T-cell receptor alpha gene transcripts in the newborn and adult periphery},
  author={S. Thompson and M. Larch{\'e} and A. R. Manzo and J. Hurwitz},
  journal={Immunogenetics},
  year={2004},
  volume={36},
  pages={95-103}
}
  • S. Thompson, M. Larché, +1 author J. Hurwitz
  • Published 2004
  • Biology, Medicine
  • Immunogenetics
  • Recent studies have demostrated that the diversity of T-cell receptor alpha (Tcra) gene expression may be confined by a developmental program for gene rearrangement. To examine the effect of age on Tcra gene usage in peripheral tissues, a comparison of Tcr transcripts from newborn and adult mouse splenocytes was made. RNA was first isolated from the spleens of newborn (within five days from birth) and adult B10.BR mice. The polymerase chain reaction was then used to assess the presence of Tcra… CONTINUE READING
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