Diversity of Prdm9 Zinc Finger Array in Wild Mice Unravels New Facets of the Evolutionary Turnover of this Coding Minisatellite

@inproceedings{Buard2014DiversityOP,
  title={Diversity of Prdm9 Zinc Finger Array in Wild Mice Unravels New Facets of the Evolutionary Turnover of this Coding Minisatellite},
  author={Jerome Buard and Eric Rivals and Denis Dunoyer de Segonzac and Charlotte Garres and Pierre Caminade and Bernard de Massy and P Boursot},
  booktitle={PloS one},
  year={2014}
}
In humans and mice, meiotic recombination events cluster into narrow hotspots whose genomic positions are defined by the PRDM9 protein via its DNA binding domain constituted of an array of zinc fingers (ZnFs). High polymorphism and rapid divergence of the Prdm9 gene ZnF domain appear to involve positive selection at DNA-recognition amino-acid positions, but… CONTINUE READING