Diversity of LEF/TCF action in development and disease


Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the nucleus by recruiting β-catenin and its co-activators to Wnt response elements (WREs) of target genes. This activity is important during development but its misregulation plays a role in disease such as cancer, where overactive Wnt signaling drives LEF/TCFs to transform… (More)
DOI: 10.1038/sj.onc.1210056


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@article{Arce2006DiversityOL, title={Diversity of LEF/TCF action in development and disease}, author={Luana M. Arce and Nobuhiro Yokoyama and Marian L. Waterman}, journal={Oncogene}, year={2006}, volume={25}, pages={7492-7504} }