Diversity of LEF/TCF action in development and disease

@article{Arce2006DiversityOL,
  title={Diversity of LEF/TCF action in development and disease},
  author={Laura Arce and Noriko N. Yokoyama and Marian L Waterman},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={7492-7504}
}
Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the nucleus by recruiting β-catenin and its co-activators to Wnt response elements (WREs) of target genes. This activity is important during development but its misregulation plays a role in disease such as cancer, where overactive Wnt signaling drives LEF/TCFs to transform cells. The size of the LEF/TCF family is small: approximately four members in vertebrates and one orthologous form in flies, worms and hydra… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 241 CITATIONS, ESTIMATED 69% COVERAGE

The role of GLI2 in human basal cell carcinoma tumourigenesis

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Lef-1 isoforms regulate different target genes and reduce cellular adhesion.

  • International journal of cancer
  • 2009
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Stem Cells and TCF Proteins: A Role for β-Catenin—Independent Functions

  • Stem Cell Reviews
  • 2007
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 24 Highly Influenced Citations

  • Averaged 15 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 119 REFERENCES