Diversity in mechanism and function of tRNA methyltransferases.

@article{Swinehart2015DiversityIM,
  title={Diversity in mechanism and function of tRNA methyltransferases.},
  author={William E Swinehart and Jane E. Jackman},
  journal={RNA biology},
  year={2015},
  volume={12 4},
  pages={398-411}
}
tRNA molecules undergo extensive post-transcriptional processing to generate the mature functional tRNA species that are essential for translation in all organisms. These processing steps include the introduction of numerous specific chemical modifications to nucleotide bases and sugars; among these modifications, methylation reactions are by far the most abundant. The tRNA methyltransferases comprise a diverse enzyme superfamily, including members of multiple structural classes that appear to… CONTINUE READING