Diversity associated with the second expressed H L A - D R B locus in the human population

Although diversity within the HLA-DRB region is predominantly focused in the DRB1 gene, the second expressed DRB loci, DRB3, DRB4, and DRB5, also exhibit variation. Within DRB1 * 15 or DRB1 * 16 haplotypes, four new variants were identified: 1) two new DRB5 alleles, DRB5 * 0104 and DRB5 * 0204, 2) a haplotype carrying a DRB1 * 15 or * 16 allele without the… CONTINUE READING