Diversity and regulation of expression of human leukocyte antigen class II molecules.

@article{Schwartz1988DiversityAR,
  title={Diversity and regulation of expression of human leukocyte antigen class II molecules.},
  author={Benjamin D. Schwartz},
  journal={The American journal of medicine},
  year={1988},
  volume={85 6A},
  pages={6-8}
}
The initiation of an immune response requires that a foreign antigen be degraded, and that one of the degradative fragments be presented in the context of a human leukocyte antigen (HLA) class II molecule to an antigen-specific helper T cell. The success of this process is maximized by the diversity of the class II molecules possessed by a given person. The expression of the HLA class II molecules is highly selective. Aberrant expression has been postulated to be responsible for autoimmune… CONTINUE READING