Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

@inproceedings{Langemeyer2014DiversityAP,
  title={Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation},
  author={Lars Langemeyer and Ricardo Nunes Bastos and Yiying Cai and Aymelt Itzen and Karin M Reinisch and Francis A Barr},
  booktitle={eLife},
  year={2014}
}
Ras superfamily GTPase activation and inactivation occur by canonical nucleotide exchange and GTP hydrolysis mechanisms. Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different Rabs. Analysis of DENND1-Rab35, Rabex-Rab5, TRAPP-Rab1 and DrrA-Rab1 suggests Rabs have the potential for… CONTINUE READING