Diversity and modulation of plasminogen activator activity in human prostate carcinoma cell lines.

@article{Lyon1995DiversityAM,
  title={Diversity and modulation of plasminogen activator activity in human prostate carcinoma cell lines.},
  author={Phil Lyon and William A. See and Yong Xu and Michael B. Cohen},
  journal={The Prostate},
  year={1995},
  volume={27 4},
  pages={179-86}
}
Baseline cellular plasminogen activator (PA) activity, and the cellular proteins responsible for variations in PA activity were evaluated in three human prostate carcinoma cell lines. Net PA activity in the cell lines PC-3, DU-145, and LNCaP was measured using a plasminogen-dependent fibrin lysis assay. These three cell lines were then analyzed to determine the specific protein(s) responsible for differences in PA activity. mRNA and protein levels of cellular urinary PA (uPA), tissue PA (tPA… CONTINUE READING