Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family.

@article{Castellano2005DiversityAF,
  title={Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family.},
  author={Sergi Castellano and Alexey V. Lobanov and Charles Chapple and Sergey V. Novoselov and Mario Albrecht and Deame Hua and Alain Lescure and Thomas Lengauer and Alain Krol and Vadim N. Gladyshev and Roderic Guig{\'o}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 45},
  pages={16188-93}
}
Selenoproteins are a diverse group of proteins that contain selenocysteine (Sec), the 21st amino acid. In the genetic code, UGA serves as a termination signal and a Sec codon. This dual role has precluded the automatic annotation of selenoproteins. Recent advances in the computational identification of selenoprotein genes have provided a first glimpse of the size, functions, and phylogenetic diversity of eukaryotic selenoproteomes. Here, we describe the identification of a selenoprotein family… CONTINUE READING