Diversity and function of group 1 innate lymphoid cells.

  title={Diversity and function of group 1 innate lymphoid cells.},
  author={Victor Cortez and Marco Colonna},
  journal={Immunology letters},
Innate lymphoid cells (ILCs) are a heterogeneous population of cells with diverse roles in immune responses. Three major groups of ILCs have been defined on the basis of similarity in their production of signature cytokines, developmental requirements, and phenotypic markers. Group 1 ILCs produce IFN-γ, express the T-box transcription factors (TF) T-bet and/or Eomesodermin (Eomes), group 2 ILCs secrete IL-5 and IL-13 and express the TF GATA-3, while group 3 ILCs produce IL-22 and IL-17 and… CONTINUE READING
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