Diversity and evolution of MicroRNA gene clusters

  title={Diversity and evolution of MicroRNA gene clusters},
  author={Yanfeng Zhang and Rui Zhang and Bing Su},
  journal={Science in China Series C: Life Sciences},
microRNA (miRNA) gene clusters are a group of miRNA genes clustered within a proximal distance on a chromosome. Although a large number of miRNA clusters have been uncovered in animal and plant genomes, the functional consequences of this arrangement are still poorly understood. Located in a polycistron, the coexpressed miRNA clusters are pivotal in coordinately regulating multiple processes, including embryonic development, cell cycles and cell differentiation. In this review, based on recent… CONTINUE READING