Diversity and Evolution in the Genome of Clostridium difficile.

  title={Diversity and Evolution in the Genome of Clostridium difficile.},
  author={Daniel R Knight and Briony Elliott and Barbara J. Chang and Timothy T. Perkins and Thomas V Riley},
  journal={Clinical microbiology reviews},
  volume={28 3},
Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-associated diarrhea in humans, presenting a significant burden to global health care systems. In the last 2 decades, PCR- and sequence-based techniques, particularly whole-genome sequencing (WGS), have significantly furthered our knowledge of the genetic diversity, evolution, epidemiology, and pathogenicity of this once enigmatic pathogen. C. difficile is taxonomically distinct from many other well-known… CONTINUE READING
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