Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces

Abstract

Interleukin-4 (IL4) is a secreted immunoregulatory cytokine critically involved in host protection from parasitic helminths [1]. Reasoning that helminths may have evolved mechanisms to antagonize IL4 to maximize their dispersal, we explored mammalian IL4 evolution. This analysis revealed evidence of diversifying selection at 15 residues, clustered in… (More)
DOI: 10.1186/1471-2148-10-223

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Cite this paper

@inproceedings{Koyanagi2010DiversifyingSA, title={Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces}, author={Madoka Koyanagi and Julie A. Kerns and Linda Haiwon Chung and Yan Zhang and Scott Anthony Brown and Tudor Moldoveanu and Harmit Singh Malik and Mark Bix}, booktitle={BMC Evolutionary Biology}, year={2010} }