Diversifying selection and concerted evolution of a type IV secretion system in Bartonella.

  title={Diversifying selection and concerted evolution of a type IV secretion system in Bartonella.},
  author={Bj{\"o}rn Nystedt and A. Carolin Frank and Mikael Thollesson and Siv G. E. Andersson},
  journal={Molecular biology and evolution},
  volume={25 2},
We have studied the evolution of a type IV secretion system (T4SS), in Bartonella, which is thought to have changed function from conjugation to erythrocyte adherence following a recent horizontal gene transfer event. The system, called Trw, is unique among T4SSs in that genes encoding both exo- and intracellular components are located within the same duplicated fragment. This provides an opportunity to study the influence of selection on proteins involved in host-pathogen interactions. We… CONTINUE READING
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