Diversified bursal medullary B cells survive and expand independently after depletion following neonatal infectious bursal disease virus infection.

@article{Withers2006DiversifiedBM,
  title={Diversified bursal medullary B cells survive and expand independently after depletion following neonatal infectious bursal disease virus infection.},
  author={David R Withers and T. Fred Davison and John Young},
  journal={Immunology},
  year={2006},
  volume={117 4},
  pages={558-65}
}
The primary immunoglobulin repertoire of chickens is generated not by gene rearrangement but by a subsequent process of gene conversion in proliferating immature B cells within the follicles of a specialized gut-associated lymphoid organ, the bursa of Fabricius. Neonatal infection with infectious bursal disease virus can eliminate almost the entire bursal B-cell compartment. Thereafter, two types of follicle reappear. Larger follicles, with rapidly proliferating B cells and normal structure… CONTINUE READING