Diversified Expression of NG2/CSPG4 Isoforms in Glioblastoma and Human Foetal Brain Identifies Pericyte Subsets

@inproceedings{Girolamo2013DiversifiedEO,
  title={Diversified Expression of NG2/CSPG4 Isoforms in Glioblastoma and Human Foetal Brain Identifies Pericyte Subsets},
  author={Francesco Girolamo and Alice Dallatomasina and Marco Rizzi and Mariella Errede and Thomas W{\"a}lchli and Maria Teresa Mucignat and Karl Frei and Luisa Roncali and Roberto Perris and Daniela Virgintino},
  booktitle={PloS one},
  year={2013}
}
NG2/CSPG4 is a complex surface-associated proteoglycan (PG) recognized to be a widely expressed membrane component of glioblastoma (WHO grade IV) cells and angiogenic pericytes. To determine the precise expression pattern of NG2/CSPG4 on glioblastoma cells and pericytes, we generated a panel of >60 mouse monoclonal antibodies (mAbs) directed against the ectodomain of human NG2/CSPG4, partially characterized the mAbs, and performed a high-resolution distributional mapping of the PG in human… CONTINUE READING