Diversification of neurotoxins by C-tail 'wiggling': a scorpion recipe for survival.

  title={Diversification of neurotoxins by C-tail 'wiggling': a scorpion recipe for survival.},
  author={Michael Gurevitz and Dalia Gordon and S Ben-Natan and Michael Turkov and Oren Froy},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={15 7},
The structure of bioactive surfaces of proteins is a subject of intensive research, yet the mechanisms by which such surfaces have evolved are largely unknown. Polypeptide toxins produced by venomous animals such as sea anemones, cone snails, scorpions, and snakes show multiple routes for active site diversification, each maintaining a typical conserved scaffold. Comparative analysis of an array of genetically related scorpion polypeptide toxins that modulate sodium channels in neuronal… CONTINUE READING

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A scorpion a - like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons

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