Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate.

@article{Li2003DiversificationOF,
  title={Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate.},
  author={Weimin Li and Mary A. Schuler and May R Berenbaum},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 Suppl 2},
  pages={14593-8}
}
Diversification of cytochrome P450 monooxygenases (P450s) is thought to result from antagonistic interactions between plants and their herbivorous enemies. However, little direct evidence demonstrates the relationship between selection by plant toxins and adaptive changes in herbivore P450s. Here we show that the furanocoumarin-metabolic activity of CYP6B proteins in two species of swallowtail caterpillars is associated with the probability of encountering host plant furanocoumarins. Catalytic… CONTINUE READING

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