Diverse stimuli engage different neutrophil extracellular trap pathways

  title={Diverse stimuli engage different neutrophil extracellular trap pathways},
  author={Elaine F Kenny and Alf Herzig and Renate Kr{\"u}ger and Aaron Muth and Santanu Mondal and Paul R Thompson and V Brinkmann and Horst von Bernuth and Arturo Zychlinsky},
Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, Candida albicans and Group B Streptococcus. We studied NET production in neutrophils from healthy donors with inhibitors of molecules crucial to PMA-induced NETs including protein kinase C, calcium, reactive oxygen species, the enzymes myeloperoxidase (MPO) and… CONTINUE READING

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