Diverse signalling of the platelet P2Y1 receptor leads to a dichotomy in platelet function.

@article{Amison2018DiverseSO,
  title={Diverse signalling of the platelet P2Y1 receptor leads to a dichotomy in platelet function.},
  author={Richard T. Amison and Shirin Jamshidi and Khondaker Miraz Rahman and Clive P Page and Simon C Pitchford},
  journal={European journal of pharmacology},
  year={2018},
  volume={827},
  pages={58-70}
}
Platelet P2Y1 receptor signalling via RhoGTPases is necessary for platelet-dependent leukocyte recruitment, where no platelet aggregation is observed. We investigated signalling cascades involved in distinct P2Y1-dependent platelet activities in vitro, using specific inhibitors for phospholipase C (PLC) (U73122, to inhibit the canonical pathway), and… CONTINUE READING