Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.

@article{Endsley2007DiverseRO,
  title={Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.},
  author={Michael P. Endsley and Nitin T. Aggarwal and Marilyn A. Isbell and Craig E. Wheelock and Bruce D Hammock and J Russel Falck and William Campbell and Kasem Nithipatikom},
  journal={International journal of cancer},
  year={2007},
  volume={121 5},
  pages={984-91}
}
Endogenous 2-arachidonoylglycerol (2-AG) is antiinvasive in androgen-independent prostate carcinoma (PC-3) cells. Invasion of PC-3 cells is also inhibited by exogenously added noladin ether, a non-hydrolyzable analog of 2-AG. In contrast, exogenous 2-AG has the opposite effect. Cell invasion significantly increased with high concentrations of exogenous 2-AG. In PC-3 cells, arachidonic acid (AA) and 12-hydroxyeicosatetraenoic acid (12-HETE) concentrations increased along with exogenously added 2… CONTINUE READING

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