Diverse roles for semaphorin-plexin signaling in the immune system.

  title={Diverse roles for semaphorin-plexin signaling in the immune system.},
  author={Hyota Takamatsu and Atsushi Kumanogoh},
  journal={Trends in immunology},
  volume={33 3},
Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several semaphorins, so-called 'immune semaphorins', are crucially involved in various phases of both physiological and pathological immune responses; some regulate immune cell activation or differentiation, whereas others navigate the trafficking of immune cells. Plexin family members are one of the most representative semaphorin… CONTINUE READING
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