Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex.

@article{Worch2009DiverseRO,
  title={Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex.},
  author={Remigiusz Worch and Marzena Jankowska-Anyszka and Anna Niedzwiecka and Janusz Stępiński and Catherine Mazza and Edward Darzynkiewicz and Stephen Cusack and Ryszard Stolarski},
  journal={Journal of molecular biology},
  year={2009},
  volume={385 2},
  pages={
          618-27
        }
}
The heterodimeric nuclear cap-binding complex (CBC) specifically recognizes the monomethylguanosine 5' cap structure of the eukaryotic RNA polymerase II transcripts such as mRNA and U snRNA. The binding is essential for nuclear maturation of mRNA, for nuclear export of U snRNA in metazoans, and for nonsense-mediated decay of mRNA and the pioneer round of translation. We analysed the recognition of the cap by native human CBC and mutants in which each tyrosine that stacks with the 7… CONTINUE READING

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