Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.

@article{Saleh2008DiversePO,
  title={Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.},
  author={Sohag N. Saleh and Anthony P Albert and Claire M Peppiatt-Wildman and William A. Large},
  journal={The Journal of physiology},
  year={2008},
  volume={586 10},
  pages={2463-76}
}
In vascular smooth muscle, store-operated channels (SOCs) contribute to many physiological functions including vasoconstriction and cell growth and proliferation. In the present work we compared the properties of SOCs in freshly dispersed myocytes from rabbit coronary and mesenteric arteries and portal vein. Cyclopiazonic acid (CPA)-induced whole-cell SOC currents were sixfold greater at negative membrane potentials and displayed markedly different rectification properties and reversal… CONTINUE READING

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