Diverse microglial responses after intrahippocampal administration of lipopolysaccharide.

@article{Herber2006DiverseMR,
  title={Diverse microglial responses after intrahippocampal administration of lipopolysaccharide.},
  author={Donna Lorraine Herber and Jessica L Maloney and Lisa Marie Roth and Melissa J. Freeman and David Morgan and Marcia N Gordon},
  journal={Glia},
  year={2006},
  volume={53 4},
  pages={382-91}
}
Inflammation has been argued to play a primary role in the pathogenesis of Alzheimer's disease by contributing to the development of neuropathology and clinical symptoms. However, the mechanisms underlying these effects remain obscure. Lipopolysaccharide (LPS) activates the innate immune response and triggers gliosis when injected into the central nervous system. In the studies described in the present work, we evaluated the time course of microgliosis after a single intrahippocampal injection… CONTINUE READING