Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment.

@article{Rateb2011DiverseMP,
  title={Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment.},
  author={Mostafa E. Rateb and Wael E Houssen and William T A Harrison and Hai Deng and Chinyere K. Okoro and Juan A. Asenjo and Barbara A. Andrews and Alan T. Bull and Michael Goodfellow and Rainer Ebel and Marcel Jaspars},
  journal={Journal of natural products},
  year={2011},
  volume={74 9},
  pages={
          1965-71
        }
}
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5… 
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A polyphasic study was carried out to establish the taxonomic status of an Atacama Desert isolate, Streptomyces strain C34T, which synthesises novel antibiotics, the chaxalactins and chaxamycins. The…
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References

SHOWING 1-10 OF 27 REFERENCES
Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp.
Streptomyces sp. strain C34, isolated from soil collected in the Chilean hyper-arid Atacama Desert, was cultured on different media, resulting in the isolation and identification of four new…
Diversity of culturable actinomycetes in hyper-arid soils of the Atacama Desert, Chile
TLDR
The results of this study support the view that arid desert soils constitute a largely unexplored repository of novel bacteria, while the high incidence of non-ribosomal peptide synthase genes in isolates recommend them as promising material in screening for new bioactive natural products.
Discovery of novel metabolites from marine actinomycetes.
  • K. S. Lam
  • Biology, Engineering
    Current opinion in microbiology
  • 2006
Spicochalasin A and New Aspochalasins from the Marine‐Derived Fungus Spicaria elegans
Different culture conditions directed by the OSMAC (one strain-many compounds) approach drastically modified the metabolites of the fungus Spicaria elegans, which yielded the novel spicochalasin A…
Alkaline protease production by an actinomycete MA1-1 isolated from marine sediments
TLDR
The inhibition profile exhibited by phenylmethylsulphonyl fluoride (PMSF) showed that this enzyme belongs to the serine-protease group.
Novel macrolactins as antibiotic lactones from a marine bacterium.
TLDR
Seven new macrolactins (named G~M) were isolated from a culture broth of Bacillus sp.
Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.
TLDR
The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510, -540, and -542, produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide are described.
cvhA gene of Streptomyces hygroscopicus 10-22 encodes a negative regulator for mycelia development.
TLDR
It is proposed that CvhA is likely a sensor histidine kinase and negatively regulates the morphological differentiation in a sugar-dependent manner in S. hygroscopicus 10-22.
Difficidin and oxydifficidin: novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. II. Isolation and physico-chemical characterization.
TLDR
The structures of the compounds represent a new class of antibiotics, characterized as highly unsaturated 22-membered macrolide phosphates as well as reversible thermal isomerization to 3 and 4 respectively.
Influence of carbon source on growth and mycotoxin production by isolates of Pyrenophora tritici-repentis from wheat.
TLDR
Differences in the growth of and mycotoxin production by isolates of P. tritici-repentis likely resulted from the differential composition of the media and (or) intraspecies variability, and the optimization of growth medium should be considered when evaluating the potential of specific isolates for mycotoxins production.
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