Diverse mechanisms regulate sporulation sigma factor activity in the Firmicutes.


Sporulation allows bacteria to survive adverse conditions and is essential to the lifecycle of some obligate anaerobes. In Bacillus subtilis, the sporulation-specific sigma factors, σ(F), σ(E), σ(G), and σ(K), activate compartment-specific transcriptional programs that drive sporulation through its morphological stages. The regulation of these sigma factors… (More)
DOI: 10.1016/j.mib.2015.01.006