Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila

@inproceedings{Urbanus2016DiverseMO,
  title={Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila
},
  author={Malene L. Urbanus and Andrew T Quaile and Peter J Stogios and Mariya Morar and Chitong Rao and Rosa Di Leo and Elena Evdokimova and Mandy Hiu Yi Lam and Christina Oatway and Marianne E. Cuff and Jerzy Osipiuk and Karolina Michalska and Boguslaw P. Nocek and Mikko Taipale and Alexei Savchenko and Alexander W Ensminger},
  booktitle={Molecular systems biology},
  year={2016}
}
Pathogens deliver complex arsenals of translocated effector proteins to host cells during infection, but the extent to which these proteins are regulated once inside the eukaryotic cell remains poorly defined. Among all bacterial pathogens, Legionella pneumophila maintains the largest known set of translocated substrates, delivering over 300 proteins to the host cell via its Type IVB, Icm/Dot translocation system. Backed by a few notable examples of effector-effector regulation in L… CONTINUE READING
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Structural and functional investigations of the effector protein LpiR1 from Legionella pneumophila

  • KA Beyrakhova, K van Straaten, L Li, MT Boniecki, DH Anderson, M Cygler
  • J Biol Chem 291:
  • 2016

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