Diverse mechanisms employed by Toxoplasma gondii to inhibit IFN-gamma-induced major histocompatibility complex class II gene expression.

@article{Lang2006DiverseME,
  title={Diverse mechanisms employed by Toxoplasma gondii to inhibit IFN-gamma-induced major histocompatibility complex class II gene expression.},
  author={Christine Lang and Michaela Algner and Nicole Beinert and U. Gross and Carsten G K L{\"u}der},
  journal={Microbes and infection},
  year={2006},
  volume={8 8},
  pages={1994-2005}
}
The intracellular parasite Toxoplasma gondii is able to establish persistent infections in immunocompetent hosts and this may be facilitated by different immune evasion mechanisms. In the present study, we describe that infection of murine monocyte/macrophage RAW 264.7 cells with T. gondii blocks the IFN-gamma-induced upregulation of major histocompatibility complex (MHC) class II mRNAs and proteins. Heat inactivation of the parasites prior to host cell invasion, but not inhibition of the… CONTINUE READING

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