Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

@inproceedings{Cole2017DiverseIT,
  title={Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions},
  author={John J. Cole and Neil A. Robertson and Mohammed Iqbal Rather and John P. Thomson and Tony McBryan and Duncan Sproul and Tina Wang and Claire Brock and William N. Clark and Trey Ideker and Richard R. Meehan and Richard L. Miller and Holly M Brown-Borg and Peter David Adams},
  booktitle={Genome Biology},
  year={2017}
}
Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “clock”, a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined age-associated DNA methylation changes at the whole-genome, single-nucleotide level in mouse liver and tested the impact of longevity-promoting interventions… CONTINUE READING
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