Diverse functions of 24(S)-hydroxycholesterol in the brain.

  title={Diverse functions of 24(S)-hydroxycholesterol in the brain.},
  author={Noriko Noguchi and Yoshiro Saito and Yasuomi Urano},
  journal={Biochemical and biophysical research communications},
  volume={446 3},
24(S)-hydroxycholesterol (24S-OHC) which is enzymatically produced in the brain plays important physiological roles in maintaining brain cholesterol homeostasis. We found that 24S-OHC at sub-lethal concentrations down-regulated amyloid precursor protein (APP) trafficking via enhancement of the complex formation of APP with up-regulated glucose-regulated… CONTINUE READING