Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

@article{Mohanraju2016DiverseER,
  title={Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems},
  author={Prarthana Mohanraju and K. Makarova and Bernd Zetsche and F. Zhang and E. Koonin and J. van der Oost},
  journal={Science},
  year={2016},
  volume={353}
}
  • Prarthana Mohanraju, K. Makarova, +3 authors J. van der Oost
  • Published 2016
  • Medicine, Biology
  • Science
  • BACKGROUND Prokaryotes have evolved multiple systems to combat invaders such as viruses and plasmids. Examples of such defense systems include receptor masking, restriction-modification (R-M) systems, DNA interference (Argonaute), bacteriophage exclusion (BREX or PGL), and abortive infection, all of which act in an innate, nonspecific manner. In addition, prokaryotes have evolved adaptive, heritable immune systems: clustered regularly interspaced palindromic repeats (CRISPR) and the CRISPR… CONTINUE READING
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    • 64
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    • 33
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    • 24
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    • 58
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    • 89
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 184 REFERENCES
    RNA-Guided Human Genome Engineering via Cas9
    • 5,931
    • PDF
    CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity.
    • 411
    Multiplex Genome Engineering Using CRISPR/Cas Systems
    • 8,939
    • PDF
    CRISPR-based adaptive and heritable immunity in prokaryotes.
    • 417
    A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
    • 7,503
    • PDF
    Degenerate target sites mediate rapid primed CRISPR adaptation
    • 195
    • PDF
    CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
    • 1,552
    • Highly Influential
    • PDF