Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

  title={Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems},
  author={Prarthana Mohanraju and K. Makarova and Bernd Zetsche and F. Zhang and E. Koonin and J. van der Oost},
  • Prarthana Mohanraju, K. Makarova, +3 authors J. van der Oost
  • Published 2016
  • Medicine, Biology
  • Science
  • BACKGROUND Prokaryotes have evolved multiple systems to combat invaders such as viruses and plasmids. Examples of such defense systems include receptor masking, restriction-modification (R-M) systems, DNA interference (Argonaute), bacteriophage exclusion (BREX or PGL), and abortive infection, all of which act in an innate, nonspecific manner. In addition, prokaryotes have evolved adaptive, heritable immune systems: clustered regularly interspaced palindromic repeats (CRISPR) and the CRISPR… CONTINUE READING
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