Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats

@article{Filip2006DiverseEO,
  title={Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats},
  author={Małgorzata Filip and Małgorzata Frankowska and Magdalena Zaniewska and Anna Gołda and Edmund Przegaliński and Jerzy Vetulani},
  journal={Psychopharmacology},
  year={2006},
  volume={192},
  pages={17-26}
}
Recent data indicate that γ-aminobutyric acid (GABA) is a modulator of behavioral responses to cocaine. The efficacy of gabapentin (a cyclic GABA analogue), tiagabine (a GABA reuptake inhibitor), or vigabatrin (an inhibitor of GABA transaminase and reuptake) to alter cocaine-seeking behavior and discriminative effects was examined in rats. Rats were trained to press a lever for cocaine (0.5 mg/kg per infusion) paired with a cue (light + tone) using a fixed ratio (FR) 5 schedule of reinforcement… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…