Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation

@article{Ess1999DiverseDM,
  title={Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation},
  author={Kevin C. Ess and David P. Witte and Charles P Bascomb and Bruce J. Aronow},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1103-1111}
}
The c-myb gene encodes a sequence specific transactivator that is required for fetal hematopoiesis, but its potential role in other tissues is less clear because of the early fetal demise of mice with targeted deletions of the c-myb gene and incomplete of knowledge about c-myb's expression pattern. In the hematopoietic system, c-Myb protein acts on target genes whose expression is restricted to individual lineages, despite Myb's presence and role in multiple immature lineages. This suggests… CONTINUE READING

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