Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues.

@article{Masuda2005DiverseCL,
  title={Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues.},
  author={Seiko Masuda and Makoto Murakami and Yukio Ishikawa and Toshiharu Ishii and Ichiro Kudo},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1736 3},
  pages={
          200-10
        }
}
The secretory phospholipase A2 (sPLA2) family in mammals contains more than 10 enzymes. In this study, we examined by immunohistochemistry the localization of six sPLA2s (IIA, IID, IIE, IIF, V and X) in human heart, kidney, liver and stomach. In normal hearts, sPLA2-IIA was detected in coronary vascular smooth muscle cells (VSMC) and sPLA2-V in cardiomyocytes beneath the endocardium. In infarcted hearts, expression of these two enzymes was markedly increased in damaged cardiomyocytes, and… CONTINUE READING
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