Diverse cellular and apoptotic responses to variant shapes of UHMWPE particles in a murine model of inflammation.

@article{Yang2002DiverseCA,
  title={Diverse cellular and apoptotic responses to variant shapes of UHMWPE particles in a murine model of inflammation.},
  author={Shang-you Yang and Weiping P Ren and Youngsoo Park and Allison Sieving and Stephen Hsu and Sam Nasser and Paul H. Wooley},
  journal={Biomaterials},
  year={2002},
  volume={23 17},
  pages={3535-43}
}
The wear of orthopaedic prostheses results in the release of a markedly heterogeneous assortment of particulate debris, with respect to both size and shape. Although particle size has been extensively examined, the role of particle shape in adverse inflammatory reactions to debris remains unclear. Using an in vivo murine model of inflammation, we assessed tissue responses to globular and to elongated ultra-high molecular weight polyethylene (UHMWPE) particles with a similar surface area, and… CONTINUE READING