Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish.

@article{Cossins2009DiverseCE,
  title={Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish.},
  author={Andrew R. Cossins and Daryl R Williams and Nick S Foulkes and Michael Berenbrink and Anja Kipar},
  journal={The Journal of experimental biology},
  year={2009},
  volume={212 Pt 5},
  pages={
          627-38
        }
}
Myoglobin (Mb) is famous as a muscle-specific protein--yet the common carp expresses the gene (cMb1) encoding this protein in a range of non-muscle tissues and also expresses a novel isoform (cMb2) in the brain. Using a homologous antibody and riboprobes, we have established the relative amounts and cellular sites of non-muscle Mb expression in different tissues. The amounts of carp myoglobin (cMb) in supernatants of different tissues were just 0.4-0.7% relative to that of heart supernatants… CONTINUE READING

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