Diverse T cell receptor beta gene usage by infiltrating T cells in the lacrimal glands of Sjögren's syndrome.

@article{Mizushima1995DiverseTC,
  title={Diverse T cell receptor beta gene usage by infiltrating T cells in the lacrimal glands of Sj{\"o}gren's syndrome.},
  author={Noboru Mizushima and Hitoshi Kohsaka and Kazuo Tsubota and Ichiro Saito and Nobuyuki Miyasaka},
  journal={Clinical and experimental immunology},
  year={1995},
  volume={101 1},
  pages={
          33-8
        }
}
Sjögren's syndrome (SS) is an autoimmune disease characterized by T cell infiltration into the salivary and lacrimal glands (LG). Previous studies on T cell receptor (TCR) usage in the minor salivary glands (SG) have yielded controversial results. We studied TCR beta gene usage of the T cells infiltrating to LG, which is the other major target organ of SS. Total RNA was extracted from fresh LG and SG biopsy samples, and peripheral blood mononuclear cells from five SS patients, and converted to… CONTINUE READING
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